Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER<sup>+</sup> breast cancer.

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作者： Kevin,Shee ^[1] ; Amanda,Jiang ^[1] ; Frederick S,Varn ^[1] ; Stephanie,Liu ^[1] ; Nicole A,Traphagen ^[1] ; Philip,Owens ^[2] ; Cynthia X,Ma ^[3] ; Jeremy,Hoog ^[4] ; Chao,Cheng ^[4] ; Todd R,Golub ^[1] ; Ravid,Straussman ^[5] ; Todd W,Miller ^[6]

作者单位： Department of Molecular and Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA. ^[1] Department of Pathology, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA. ^[2] Department of Veterans Affairs, Research Medicine, Eastern Colorado Health Care System, Denver, Colorado, USA. ^[3] Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA. ^[4] Department of Biomedical Data Sciences, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA. ^[5] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA. ^[6] Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel. ^[7] Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA. ^[8]

关键词 CDK4 CDK6 anti-estrogen estrogen receptor