Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin.-论文-万方医学网

作者： Yong,Zhang ^[1] ; Yinhui,Dong ^[1] ; Michael W,Melkus ^[2] ; Shutao,Yin ^[1] ; Su-Ni,Tang ^[1] ; Peixin,Jiang ^[2] ; Kartick,Pramanik ^[1] ; Wei,Wu ^[1] ; Sangyub,Kim ^[1] ; Min,Ye ^[3] ; Hongbo,Hu ^[1] ; Junxuan,Lu ^[3] ; Cheng,Jiang ^[3]

作者单位： Department of Biomedical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas. ^[1] Department of Nutrition and Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China. ^[2] Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania. ^[3] The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China. ^[4] Department of Biomedical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas. cjiang@pennstatehealth.psu.edu junxuanlu@pennstatehealth.psu.edu. ^[5] Penn State Cancer Institute, Pennsylvania State University, Hershey, Pennsylvania. ^[6]

主题词动物(Animals);细胞凋亡(Apoptosis);自噬(Autophagy);蟾酥甾类(Bufanolides);强心药(Cardiotonic Agents);半胱氨酸天冬氨酸蛋白酶(Caspases);细胞周期(Cell Cycle);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);周期素依赖激酶抑制剂p21(Cyclin-Dependent Kinase Inhibitor p21);DNA损伤(DNA Damage);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);男(雄)性(Male);小鼠, SCID(Mice, SCID);表型(Phenotype);前列腺肿瘤(Prostatic Neoplasms);受体, 雄激素(Receptors, Androgen);应激, 生理学(Stress, Physiological);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);增量调节(Up-Regulation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.1158/1535-7163.MCT-17-1296

PMID 30166403

发布时间 2020-09-30

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Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin.

Molecular cancer therapeutics

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Molecular cancer therapeutics

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Role of P53-Senescence Induction in Suppression of LNCaP Prostate Cancer Growth by Cardiotonic Compound Bufalin.

Molecular cancer therapeutics

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Molecular cancer therapeutics

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