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Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer.

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第一作者： Kristiaan J,Lenos

第一单位： Amsterdam UMC, University of Amsterdam, LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam, The Netherlands.

作者： Kristiaan J,Lenos ^[1] ; Daniël M,Miedema ^[1] ; Sophie C,Lodestijn ^[1] ; Lisanne E,Nijman ^[1] ; Tom,van den Bosch ^[1] ; Xavier,Romero Ros ^[1] ; Filipe C,Lourenço ^[2] ; Maria C,Lecca ^[1] ; Maartje,van der Heijden ^[1] ; Sanne M,van Neerven ^[1] ; Anita,van Oort ^[1] ; Nicolas,Leveille ^[1] ; Ronja S,Adam ^[1] ; Felipe,de Sousa E Melo ^[3] ; Joy,Otten ^[1] ; Patrick,Veerman ^[1] ; Guillaume,Hypolite ^[1] ; Lianne,Koens ^[4] ; Scott K,Lyons ^[5] ; Giorgio,Stassi ^[6] ; Douglas J,Winton ^[2] ; Jan Paul,Medema ^[1] ; Edward,Morrissey ^[7] ; Maarten F,Bijlsma ^[1] ; Louis,Vermeulen ^[8]

作者单位： Amsterdam UMC, University of Amsterdam, LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam, The Netherlands. ^[1] Cancer Research UK, Cambridge Institute, University of Cambridge, Cambridge, UK. ^[2] Department of Discovery Oncology, Genentech, South San Francisco, CA, USA. ^[3] Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. ^[4] Preclinical Imaging, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. ^[5] Cellular & Molecular Pathophysiology Laboratory, Department of Surgical & Oncological Sciences, University of Palermo, Palermo, Italy. ^[6] MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK. ^[7] Amsterdam UMC, University of Amsterdam, LEXOR, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam and Amsterdam Gastroenterology & Metabolism, Amsterdam, The Netherlands. l.vermeulen@amc.uva.nl. ^[8]