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The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils.

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第一作者： Akshay A,D'Cruz

第一单位： Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

作者： Akshay A,D'Cruz ^[1] ; Mary,Speir ^[1] ; Meghan,Bliss-Moreau ^[1] ; Sylvia,Dietrich ^[1] ; Shu,Wang ^[2] ; Alyce A,Chen ^[1] ; Mathilde,Gavillet ^[3] ; Arshed,Al-Obeidi ^[2] ; Kate E,Lawlor ^[4] ; James E,Vince ^[4] ; Michelle A,Kelliher ^[5] ; Razq,Hakem ^[6] ; Manolis,Pasparakis ^[7] ; David A,Williams ^[1] ; Maria,Ericsson ^[8] ; Ben A,Croker ^[9]

作者单位： Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. ^[1] Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA. ^[2] Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.;Department of Hematology, Lausanne University Hospital, 1011 Lausanne, Switzerland. ^[3] Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville 3052, Australia. ^[4] Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA. ^[5] Ontario Cancer Institute, University Health Network, and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada. ^[6] Institute for Genetics, Center for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany. ^[7] Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. ^[8] Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA 02115, USA. ben.croker@childrens.harvard.edu.;Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. ^[9]