换一批Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin.
第一作者：
Brie K,Fuqua
第一单位：
Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, California.;Iron Metabolism Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
作者：
关键词
CP, ceruloplasminCp-/-, mice lacking CP in the whole bodyDAB, 3,3′-diaminobenzidineFDR, false discovery rateFPN1, ferroportin 1GI, gastrointestinalHCI, hydrochloric acidHEPH, hephaestinHeph-/-, mice lacking HEPH in the whole bodyHeph-/-Cp-/- or DKO, double-knockout mice lacking both HEPH and CPHephfl/fl, mice with floxed Heph allelesHephfl/flCp-/-, mice with floxed Heph alleles and lacking CP in the whole bodyHephint/int, mice lacking HEPH in the intestine aloneHephint/intCp-/-, mice lacking HEPH in the intestine alone and lacking CP in the whole bodyHephsla/slaCp-/-, mice lacking CP in the whole body and expressing only the sla mutant form of HEPHIntestinal Iron AbsorptionIron Deficiency AnemiaIron OverloadMCF, multicopper ferroxidaseNTBI, non-transferrin bound ironNon-Transferrin Bound IronPBS, phosphate-buffered salinePCR, polymerase chain reactionSD, standard deviationTBST, Tris-buffered saline with 0.1 Tween-20TF, transferrinTIBC, total iron binding capacityWT, wild-typesla, sex-linked anemia
医学主题词
贫血(Anemia);动物(Animals);动物, 吮乳期(Animals, Suckling);身体测量(Body Size);体重(Body Weight);阳离子转运蛋白质类(Cation Transport Proteins);血浆铜蓝蛋白(Ceruloplasmin);疾病模型, 动物(Disease Models, Animal);十二指肠(Duodenum);肠细胞(Enterocytes);女(雌)性(Female);铁(Iron);结扎术(Ligation);男(雄)性(Male);膜蛋白质类(Membrane Proteins);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);器官特异性(Organ Specificity);表型(Phenotype)
DOI
10.1016/j.jcmgh.2018.06.006
PMID
30182051
发布时间
2025-01-03
- 浏览3
Cellular and molecular gastroenterology and hepatology
2018年6卷4期
405-427页
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