首页> Metabolic brain disease> EGb761 improves the cognitive function of elderly db/db<sup>-/-</sup> diabetic mice by regulating the beclin-1 and NF-κB signaling pathways.

EGb761 improves the cognitive function of elderly db/db<sup>-/-</sup> diabetic mice by regulating the beclin-1 and NF-κB signaling pathways.

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第一作者： Zhu-Fei,Guan

第一单位： Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.;State Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China.

作者： Zhu-Fei,Guan ^[1] ; Xiao-Ming,Zhang ^[2] ; Ying-Hong,Tao ^[3] ; Yu,Zhang ^[2] ; Yan-Yan,Huang ^[2] ; Gang,Chen ^[2] ; Wei-Jun,Tang ^[4] ; Gang,Ji ^[5] ; Qi-Lin,Guo ^[5] ; Ming,Liu ^[5] ; Qian,Zhang ^[5] ; Na-Na,Wang ^[2] ; Zhong-Yu,Yu ^[2] ; Hao-Yang ^[2] ; Guo-Feng,Wu ^[6] ; Zhou-Ping,Tang ^[7] ; Zun-Guo,Du ^[8] ; Xi-Liang,Shang ^[9] ; Ying-Chao,Liu ^[10] ; Guang-Hai,Mei ^[11] ; Jing-Chun,Guo ^[12] ; Hou-Guang,Zhou ^[13]

作者单位： Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China.;State Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China. ^[1] Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. ^[2] Department of Medical Examination Center, Huashan Hospital, Fudan University, Shanghai, 200040, China. ^[3] Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, China. ^[4] State Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China. ^[5] Department of Emergency Neurology, Guiyang Medical University, Guiyang, 550004, China. ^[6] Department of Neurology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430000, China. ^[7] Department of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China. ^[8] Department of Sport Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. ^[9] Department of Neurosurgery, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China. ^[10] Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. meighai@126.com. ^[11] State Key Laboratory of Medical Neurobiology, Department of Neurobiology, School of Basic Medical Neurobiology, Department of Neurobiology School of Basic Medical Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China. jingchunguo@shmu.edu.cn. ^[12] Department of Geriatrics, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China. zhg7376@163.com. ^[13]

关键词 Autophagy Beclin-1 Cognitive function EGb761 LC3-II/I NF-κB protein