Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.-论文-万方医学网

第一作者： Se Hoon,Choi

第一单位： Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

作者： Se Hoon,Choi ^[1] ; Enjana,Bylykbashi ^[1] ; Zena K,Chatila ^[1] ; Star W,Lee ^[2] ; Benjamin,Pulli ^[3] ; Gregory D,Clemenson ^[2] ; Eunhee,Kim ^[1] ; Alexander,Rompala ^[1] ; Mary K,Oram ^[1] ; Caroline,Asselin ^[1] ; Jenna,Aronson ^[1] ; Can,Zhang ^[1] ; Sean J,Miller ^[1] ; Andrea,Lesinski ^[1] ; John W,Chen ^[3] ; Doo Yeon,Kim ^[1] ; Henriette,van Praag ^[4] ; Bruce M,Spiegelman ^[5] ; Fred H,Gage ^[2] ; Rudolph E,Tanzi ^[6]

作者单位： Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. ^[1] Laboratoy of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. ^[2] Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. ^[3] Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA. ^[4] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. ^[5] Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. tanzi@helix.mgh.harvard.edu. ^[6]

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);动物(Animals);脑源性神经营养因子(Brain-Derived Neurotrophic Factor);卡唑类(Carbazoles);细胞死亡(Cell Death);认知(Cognition);疾病模型, 动物(Disease Models, Animal);运动(Exercise)(Exercise);女(雌)性(Female);纤连蛋白类(Fibronectins);海马(Hippocampus);人类(Humans);白细胞介素6(Interleukin-6);男(雄)性(Male);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);神经发生(Neurogenesis);身体条件作用, 动物(Physical Conditioning, Animal)

DOI 10.1126/science.aan8821

PMID 30190379

发布时间 2024-06-10

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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.

Science (New York, N.Y.)

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Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.

Science (New York, N.Y.)

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Science (New York, N.Y.)

相关期刊

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