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首页> Neurobiology of disease> Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease.

Microbiome profiling reveals gut dysbiosis in a transgenic mouse model of Huntington's disease.

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作者： Geraldine,Kong ^[1] ; Kim-Anh Lê,Cao ^[2] ; Louise M,Judd ^[3] ; ShanShan,Li ^[1] ; Thibault,Renoir ^[1] ; Anthony J,Hannan ^[4]

作者单位： Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne Brain Centre, Parkville, VIC 3010, Australia. ^[1] Melbourne Integrative Genomics, School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3010, Australia. ^[2] Bio21 Institute and Department of Biochemistry and Molecular Biology, University of Melbourne, Parkville, VIC 3010, Australia. ^[3] Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne Brain Centre, Parkville, VIC 3010, Australia; Department of Anatomy and Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: anthony.hannan@florey.edu.au. ^[4]

关键词 Gut microbiome Gut-brain axis Intestinal bacteria Microbiota Neurodegenerative disease Peripheral dysfunction Polyglutamine disease Sexual dimorphism Tandem repeat disorder Transgenic mice

主题词动物(Animals);脑(Brain);疾病模型, 动物(Disease Models, Animal);杭廷顿病(Huntington Disease);男(雄)性(Male);小鼠, 转基因(Mice, Transgenic);运动活动(Motor Activity);神经组织蛋白质类(Nerve Tissue Proteins);三核苷酸重复扩增(Trinucleotide Repeat Expansion)

DOI 10.1016/j.nbd.2018.09.001

PMID 30194046

发布时间 2021-01-15

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