Loading studies of the anticancer drug camptothecin into dual stimuli-sensitive nanoparticles. Stability scrutiny.

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作者： Nieves,Iglesias ^[1] ; Elsa,Galbis ^[1] ; M Jesús,Díaz-Blanco ^[2] ; M-Violante,de-Paz ^[3] ; Juan A,Galbis ^[1]

作者单位： Dpto. Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Seville, Spain. ^[1] PRO2TECS. Departamento de Ingeniería Química, Facultad de Ciencias Experimentales, Campus El Carmen, 21071 Huelva, Spain. ^[2] Dpto. Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, 41012 Seville, Spain. Electronic address: vdepaz@us.es. ^[3]

关键词 Anticancer therapy CPT: camptothecin Core cross-linked nanoparticles DEAEMA: N,N-diethylaminoethyl methacrylate DMAEMA: N,N-dimethylaminoethyl methacrylate DMDOO: 1,8-dimaleimide-3,6-dioxaoctane Drug delivery systems Experimental design FMA: furfuryl methacrylate HEMA: 2-hydroxyethyl methacrylate Kinetic drug loading pH-responsive nanoparticles polyHEMA

主题词抗肿瘤药, 植物(Antineoplastic Agents, Phytogenic);喜树碱(Camptothecin);药物载体(Drug Carriers);药物稳定性(Drug Stability);纳米粒子(Nanoparticles)

DOI 10.1016/j.ijpharm.2018.08.026

PMID 30196142

发布时间 2019-01-07

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