Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis.

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第一作者： Mina,Nekouei

第一单位： Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.

作者： Mina,Nekouei ^[1] ; Parviz,Ghezellou ^[1] ; Atousa,Aliahmadi ^[2] ; Sareh,Arjmand ^[3] ; Mahmoud,Kiaei ^[4] ; Alireza,Ghassempour ^[5]

作者单位： Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. ^[1] Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. ^[2] Protein Research Center, Shahid Beheshti University, G.C., Evin, Tehran, Iran. ^[3] Department of Pharmacology and Toxicology, Department of Neurology, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. mkiaei@uams.edu. ^[4] Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. a-ghassempour@sbu.ac.ir. ^[5]

关键词 ALS Actin binding domain Aggregation PFN1G118V PFN1WT

主题词肌萎缩侧索硬化(Amyotrophic Lateral Sclerosis);人类(Humans);突变(Mutation);肌动蛋白抑制蛋白质类(Profilins);蛋白质结构, 二级(Protein Structure, Secondary);重组蛋白质类(Recombinant Proteins)

DOI 10.1007/s11011-018-0305-4

PMID 30203378

发布时间 2019-12-01

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