Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS.

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第一作者： Shunsuke,Kitajima

第一单位： Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

作者： Shunsuke,Kitajima ^[1] ; Hajime,Asahina ^[2] ; Ting,Chen ^[3] ; Sujuan,Guo ^[4] ; Laura Gutierrez,Quiceno ^[5] ; Jillian D,Cavanaugh ^[1] ; Ashley A,Merlino ^[1] ; Shoichiro,Tange ^[6] ; Hideki,Terai ^[1] ; Jong Wook,Kim ^[7] ; Xiaoen,Wang ^[4] ; Shan,Zhou ^[4] ; Man,Xu ^[4] ; Stephen,Wang ^[4] ; Zehua,Zhu ^[1] ; Tran C,Thai ^[1] ; Chiaki,Takahashi ^[8] ; Yujin,Wang ^[9] ; Richard,Neve ^[9] ; Susanna,Stinson ^[9] ; Pablo,Tamayo ^[10] ; Hideo,Watanabe ^[11] ; Paul T,Kirschmeier ^[4] ; Kwok-Kin,Wong ^[3] ; David A,Barbie ^[12]

作者单位： Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. ^[1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; First Department of Medicine, Hokkaido University School of Medicine, Sapporo 060-8638, Japan. ^[2] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA. ^[3] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA. ^[4] Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA. ^[5] Department of Human Genetics, Graduate School of Biomedical Science, Tokushima University, Tokushima 770-8503, Japan. ^[6] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. ^[7] Division of Oncology and Molecular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan. ^[8] Gilead Sciences, Foster City, CA 94404, USA. ^[9] Moores Cancer Center and School of Medicine, University of California San Diego, La Jolla, CA 92093, USA. ^[10] Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[11] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address: dbarbie@partners.org. ^[12]

关键词 BET inhibitor IL-6 KRAS MEK inhibitor STK11/LKB1 TBK1 inhibitor TP53 YAP1 signaling innate immune signaling non-small-cell lung cancer