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首页> Phytomedicine : international journal of phytotherapy and phytopharmacology> Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells.

Rhein augments ATRA-induced differentiation of acute promyelocytic leukemia cells.

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作者： Sook-Kyoung,Heo ^[1] ; Eui-Kyu,Noh ^[2] ; Jeong Yi,Kim ^[1] ; SungHoo,Jegal ^[1] ; Yookyung,Jeong ^[1] ; Jaekyung,Cheon ^[2] ; SuJin,Koh ^[2] ; Jin Ho,Baek ^[2] ; Young Joo,Min ^[2] ; Yunsuk,Choi ^[3] ; Jae-Cheol,Jo ^[4]

作者单位： Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Republic of Korea. ^[1] Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Republic of Korea. ^[2] Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Republic of Korea; Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Republic of Korea. ^[3] Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Republic of Korea; Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 44033, Republic of Korea. Electronic address: jcjo97@hanmail.net. ^[4]

关键词 Acute promyeloid leukemia All-trans retinoic acid Anti-leukemic activity Cytotoxicity Differentiation Rhein

主题词蒽醌类(Anthraquinones);抗肿瘤药(Antineoplastic Agents);细胞凋亡(Apoptosis);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);细胞死亡(Cell Death);细胞分化(Cell Differentiation);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);白血病, 早幼粒细胞, 急性(Leukemia, Promyelocytic, Acute);巨噬细胞(Macrophages);膜电位, 线粒体(Membrane Potential, Mitochondrial);吞噬作用(Phagocytosis);活性氧(Reactive Oxygen Species);受体, CCR1(Receptors, CCR1);受体, CCR2(Receptors, CCR2);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);维甲酸(Tretinoin)

DOI 10.1016/j.phymed.2018.06.027

PMID 30217263

发布时间 2021-12-04

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