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首页> Developmental biology> A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development.

A spontaneous mouse deletion in Mctp1 uncovers a long-range cis-regulatory region crucial for NR2F1 function during inner ear development.

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第一作者： Basile,Tarchini

第一单位： The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Medicine, Tufts University, Boston 02111, MA, USA; Graduate School of Biomedical Science and Engineering (GSBSE), University of Maine, Orono 04469, ME, USA. Electronic address: basile.tarchini@jax.org.

作者： Basile,Tarchini ^[1] ; Chantal,Longo-Guess ^[2] ; Cong,Tian ^[3] ; Abigail L D,Tadenev ^[2] ; Nicholas,Devanney ^[2] ; Kenneth R,Johnson ^[4]

作者单位： The Jackson Laboratory, Bar Harbor, ME 04609, USA; Department of Medicine, Tufts University, Boston 02111, MA, USA; Graduate School of Biomedical Science and Engineering (GSBSE), University of Maine, Orono 04469, ME, USA. Electronic address: basile.tarchini@jax.org. ^[1] The Jackson Laboratory, Bar Harbor, ME 04609, USA. ^[2] The Jackson Laboratory, Bar Harbor, ME 04609, USA; Graduate School of Biomedical Science and Engineering (GSBSE), University of Maine, Orono 04469, ME, USA. ^[3] The Jackson Laboratory, Bar Harbor, ME 04609, USA. Electronic address: ken.johnson@jax.org. ^[4]

关键词 Cis-regulation Deafness Inner ear development Long-range enhancer Mctp1 Nr2f1

主题词动物(Animals);COUP转录因子Ⅰ(COUP Transcription Factor I);聋(Deafness);内耳(Ear, Inner);增强子元件, 遗传学(Enhancer Elements, Genetic);女(雌)性(Female);基因缺失(Gene Deletion);基因表达调控, 发育期(Gene Expression Regulation, Developmental);基因敲除技术(Gene Knockout Techniques);人类(Humans);男(雄)性(Male);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL)

DOI 10.1016/j.ydbio.2018.09.011

PMID 30217595

发布时间 2024-06-10

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Developmental biology

Developmental biology

2018年443卷2期

153-164页

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