论文期刊

取消

高级检索

检索历史清除

首页> Journal of enzyme inhibition and medicinal chemistry> Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design.

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design.

导出 OA

翻译打印收藏纠错

作者： Joana,Magalhães ^[1] ; Nina,Franko ^[2] ; Giannamaria,Annunziato ^[1] ; Martin,Welch ^[3] ; Stephen K,Dolan ^[3] ; Agostino,Bruno ^[4] ; Andrea,Mozzarelli ^[2] ; Stefano,Armao ^[5] ; Aigars,Jirgensons ^[6] ; Marco,Pieroni ^[7] ; Gabriele,Costantino ^[8] ; Barbara,Campanini ^[1]

作者单位： a P4T group, Department of Food and Drug , University of Parma , Parma , Italy. ^[1] b Laboratory of Biochemistry and Molecular Biology, Department of Food and Drug , University of Parma , Parma , Italy. ^[2] c Department of Biochemistry , Cambridge University , Cambridge , United Kingdom. ^[3] d Experimental Therapeutics Program , IFOM - The FIRC Institute for Molecular Oncology Foundation , Milano , Italy. ^[4] e National Institute of Biostructures and Biosystems , Rome , Italy. ^[5] f Institute of Biophysics, CNR , Pisa , Italy. ^[6] g Centro Interdipartimentale "Biopharmanet-tec", Università degli Studi di Parma , Parma , Italy. ^[7] h Latvian Institute of Organic Synthesis , Riga , Latvia. ^[8] i Centro Interdipartimentale Misure (CIM)'G. Casnati', University of Parma , Parma , Italy. ^[9]

关键词 O-acetylserine sulphhydrylase Scaffold hopping fragments ligand-based drug design medicinal chemistry pyrazoles

主题词抗菌药(Anti-Bacterial Agents);细菌(Bacteria);结合部位(Binding Sites);生物学鉴定法(Biological Assay);计算机模拟(Computer Simulation);半胱氨酸合酶(Cysteine Synthase);DNA, 重组(DNA, Recombinant);药物设计(Drug Design);配体(Ligands);模型, 分子(Models, Molecular);小分子化合物库(Small Molecule Libraries);构效关系(Structure-Activity Relationship)

DOI 10.1080/14756366.2018.1512596

PMID 30221554

发布时间 2018-11-14

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览6

Journal of enzyme inhibition and medicinal chemistry

Journal of enzyme inhibition and medicinal chemistry

2018年33卷1期

1444-1452页

相似文献

中文期刊
外文期刊
学位论文
会议论文

浏览6

Journal of enzyme inhibition and medicinal chemistry

点击下载本期目录封面

Journal of enzyme inhibition and medicinal chemistry

2018年33卷1期

1444-1452页

相关期刊

特别提示：本网站仅提供医学学术资源服务，不销售任何药品和器械，有关药品和器械的销售信息，请查阅其他网站。

客服热线：4000-115-888 转3 (周一至周五：8:00至17:00)
|
客服邮箱：yiyao@wanfangdata.com.cn

违法和不良信息举报电话：4000-115-888，举报邮箱：problem@wanfangdata.com.cn，举报专区

官方微信

万方医学小程序

关于我们网站地图知识产权

北京万方数据股份有限公司

万方数据电子出版社

京ICP证010071号

京公网安备11010802020237号

京ICP备08100800号-1

违法和不良信息举报电话：4000-115-888，举报邮箱：problem@wanfangdata.com.cn，举报专区

new翻译充值订阅收藏移动端

官方微信

万方医学小程序

调查问卷