Impact of Polymer Bioconjugation on Protein Stability and Activity Investigated with Discrete Conjugates: Alternatives to PEGylation.

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第一作者： Josefine,Morgenstern

第一单位： Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering , Karlsruhe Institute of Technology (KIT) , Fritz-Haber-Weg 2 , 76131 Karlsruhe , Germany.

作者： Josefine,Morgenstern ^[1] ; Gabriela,Gil Alvaradejo ^[2] ; Nicolai,Bluthardt ^[3] ; Ana,Beloqui ^[1] ; Guillaume,Delaittre ^[2] ; Jürgen,Hubbuch ^[3]

作者单位： Institute of Engineering in Life Sciences, Section IV: Biomolecular Separation Engineering , Karlsruhe Institute of Technology (KIT) , Fritz-Haber-Weg 2 , 76131 Karlsruhe , Germany. ^[1] Institute of Toxicology and Genetics (ITG) , Karlsruhe Institute of Technology (KIT) , Hermann-von-Helmholtz-Platz 1 , 76344 Eggenstein-Leopoldshafen , Germany. ^[2] Macromolecular Architectures, Institute for Chemical Technology and Polymer Chemistry (ITCP) , Karlsruhe Institute of Technology (KIT) , 76131 Karlsruhe , Germany. ^[3]

主题词酶稳定性(Enzyme Stability);甲基丙烯酸盐(Methacrylates);胞壁质酶(Muramidase);聚乙烯二醇类(Polyethylene Glycols);聚合物(Polymers)

DOI 10.1021/acs.biomac.8b01020

PMID 30222929

发布时间 2019-10-24

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