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Novel Statistical Designs for Phase I/II and Phase II Clinical Trials With Dose-Finding Objectives.

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第一作者： Oleksandr,Sverdlov

第一单位： 1 Integrated Information Sciences, Novartis Institutes for Biomedical Research, East Hanover, NJ, USA.

作者： Oleksandr,Sverdlov ^[1] ; Weng Kee,Wong ^[2]

作者单位： 1 Integrated Information Sciences, Novartis Institutes for Biomedical Research, East Hanover, NJ, USA. ^[1] 2 Department of Biostatistics, Fielding School of Public Health, University of California-Los Angeles, Los Angeles, CA, USA. ^[2]

关键词 Bayesian designs dose finding minimum efficacious dose optimal adaptive designs seamless phase I/II up-and-down designs

DOI 10.1177/2168479014523765

PMID 30231452

发布时间 2020-01-03

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Therapeutic innovation & regulatory science

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Novel Statistical Designs for Phase I/II and Phase II Clinical Trials With Dose-Finding Objectives.

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Novel Statistical Designs for Phase I/II and Phase II Clinical Trials With Dose-Finding Objectives.

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