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首页> Journal of virology> T5 Exonuclease Hydrolysis of Hepatitis B Virus Replicative Intermediates Allows Reliable Quantification and Fast Drug Efficacy Testing of Covalently Closed Circular DNA by PCR.

T5 Exonuclease Hydrolysis of Hepatitis B Virus Replicative Intermediates Allows Reliable Quantification and Fast Drug Efficacy Testing of Covalently Closed Circular DNA by PCR.

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作者： Bingqian,Qu ^[1] ; Yi,Ni ^[1] ; Florian A,Lempp ^[2] ; Florian W R,Vondran ^[1] ; Stephan,Urban ^[2]

作者单位： Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany. ^[1] German Centre for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany. ^[2] Regenerative Medicine and Experimental Surgery (ReMediES), Department of General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany. ^[3] German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Braunschweig, Germany. ^[4] Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany Stephan.Urban@med.uni-heidelberg.de. ^[5]

关键词 Myrcludex B T5 exonuclease cccDNA covalently closed circular DNA hepatitis B virus

主题词抗病毒药(Antiviral Agents);DNA复制(DNA Replication);DNA, 环状(DNA, Circular);DNA, 病毒(DNA, Viral);外切核酸酶类(Exonucleases);Hep G2细胞(Hep G2 Cells);乙型肝炎病毒(Hepatitis B virus);乙型肝炎, 慢性(Hepatitis B, Chronic);肝细胞(Hepatocytes);人类(Humans);水解作用(Hydrolysis);聚合酶链反应(Polymerase Chain Reaction);病毒复制(Virus Replication)

DOI 10.1128/JVI.01117-18

PMID 30232183

发布时间 2019-10-18

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Journal of virology

Journal of virology

2018年92卷23期

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