Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV.

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作者： Geetha H,Mylvaganam ^[1] ; Lynette S,Chea ^[2] ; Gregory K,Tharp ^[1] ; Sakeenah,Hicks ^[2] ; Vijayakumar,Velu ^[2] ; Smita S,Iyer ^[1] ; Claire,Deleage ^[2] ; Jacob D,Estes ^[1] ; Steven E,Bosinger ^[2] ; Gordon J,Freeman ^[1] ; Rafi,Ahmed ^[2] ; Rama R,Amara ^[3]

作者单位： Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA. ^[1] Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. ^[2] AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland, USA. ^[3] Department of Medical Oncology and Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. ^[4]

关键词 AIDS/HIV Immunology Immunotherapy

主题词动物(Animals);抗逆转录病毒药(Anti-Retroviral Agents);抗体, 单克隆(Antibodies, Monoclonal);B-淋巴细胞(B-Lymphocytes);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞增殖(Cell Proliferation);综合疗法(Combined Modality Therapy);疾病模型, 动物(Disease Models, Animal);颗粒酶类(Granzymes);HIV感染(HIV Infections);HIV-1(HIV-1);免疫疗法(Immunotherapy);Ki-67抗原(Ki-67 Antigen);猕猴(Macaca mulatta);猴获得性免疫缺陷综合征(Simian Acquired Immunodeficiency Syndrome);病毒血症(Viremia)

DOI 10.1172/jci.insight.122940

PMID 30232277

发布时间 2024-06-15

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Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV.

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Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV.

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