Quantitative Laser Diffraction for Quantification of Protein Aggregates: Comparison With Resonant Mass Measurement, Nanoparticle Tracking Analysis, Flow Imaging, and Light Obscuration.

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第一作者： Saki,Yoneda

第一单位： Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565-0871 Osaka, Japan.

作者： Saki,Yoneda ^[1] ; Bertram,Niederleitner ^[2] ; Michael,Wiggenhorn ^[2] ; Hiroki,Koga ^[1] ; Shinichiro,Totoki ^[3] ; Elena,Krayukhina ^[1] ; Wolfgang,Friess ^[4] ; Susumu,Uchiyama ^[5]

作者单位： Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565-0871 Osaka, Japan. ^[1] Coriolis Pharma, Fraunhoferstraße 18 b, 82152 Martinsried, Germany. ^[2] Shimadzu Corporation, 1, Nishinokyo Kuwabara-cho, Nakagyo-ku, Kyoto 604-8511, Japan. ^[3] Department of Pharmacy, Pharmaceuical Technology and Biopharmaceuticals, Ludwig-Maximilians-Universität, Butenandtstrasse 5, 81377 München, Germany. ^[4] Department of Biotechnology, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565-0871 Osaka, Japan; Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan. Electronic address: suchi@bio.eng.osaka-u.ac.jp. ^[5]

关键词 antibody(s)biopharmaceutical characterization microparticle(s)nanoparticle(s)protein aggregation protein formulation(s)