G1 phase cell cycle arrest in NSCLC in response to LZ-106, an analog of enoxacin, is orchestrated through ROS overproduction in a P53-dependent manner.

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第一作者： Lin,Yang

第一单位： State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Tongjiaxiang, Nanjing, China.

作者： Lin,Yang ^[1] ; Jieying,Zhou ^[1] ; Fei,Meng ^[2] ; Chengyu,Fu ^[1] ; Xiaoqian,Zou ^[1] ; Jinfeng,Liu ^[1] ; Chengwan,Zhang ^[3] ; Renxiang,Tan ^[4] ; Zhiyu,Li ^[5] ; Qinglong,Guo ^[1] ; Libin,Wei ^[1]

作者单位： State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Tongjiaxiang, Nanjing, China. ^[1] Department of Clinical Laboratory, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, China. ^[2] The Central Laboratory of Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu Province, China. ^[3] State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing, China. ^[4] Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Tongjiaxiang, Nanjing, China. ^[5]