Dietary grape seed procyanidin extract protects against lead-induced heart injury in rats involving endoplasmic reticulum stress inhibition and AKT activation.

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第一作者： Daqian,Yang

第一单位： College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin 150030, China.

作者： Daqian,Yang ^[1] ; Siyu,Li ^[2] ; Li,Gao ^[3] ; Zhanjun,Lv ^[3] ; Qizheng,Bing ^[2] ; Qingjie,Lv ^[4] ; Xiaoyan,Zheng ^[4] ; Ruobing,Li ^[4] ; Zhigang,Zhang ^[5]

作者单位： College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin 150030, China. ^[1] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China. ^[2] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China. ^[3] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China. ^[4] College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China. Electronic address: zhangzhigang@neau.edu.cn. ^[5]

关键词 AKT activation Endoplasmic reticulum stress Grape seed procyanidin extract Heart injury Lead Therapy