Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.

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作者： Giusy,Tassone ^[1] ; Stefano,Mangani ^[1] ; Maurizio,Botta ^[2] ; Cecilia,Pozzi ^[3]

作者单位： Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro, 2, 53100 Siena (SI), Italy. ^[1] Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro, 2, 53100 Siena (SI), Italy; Lead Discovery Siena S.r.l., Castelnuovo Berardenga, Siena, Italy; Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, United States. ^[2] Department of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, via Aldo Moro, 2, 53100 Siena (SI), Italy. Electronic address: pozzi4@unisi.it. ^[3]

关键词 Heat shock protein 90 Leishmania braziliensis Nucleotides Protozoan parasites Selectivity X-ray crystallography

主题词腺苷三磷酸(Adenosine Triphosphate);结合部位(Binding Sites);巴西(Brazil);克隆, 分子(Cloning, Molecular);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);水解作用(Hydrolysis);巴西利什曼原虫(Leishmania braziliensis);分子伴侣(Molecular Chaperones);诱变, 定点(Mutagenesis, Site-Directed);蛋白质结合(Protein Binding);蛋白质构象(Protein Conformation);原虫蛋白质类(Protozoan Proteins)

DOI 10.1016/j.bbapap.2018.09.005

PMID 30248409

发布时间 2018-12-17

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Biochimica et biophysica acta. Proteins and proteomics

2018年1866卷11期

1190-1198页

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Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.

Biochimica et biophysica acta. Proteins and proteomics

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Biochimica et biophysica acta. Proteins and proteomics

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Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.

Biochimica et biophysica acta. Proteins and proteomics

相似文献

Biochimica et biophysica acta. Proteins and proteomics

相关期刊

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