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首页> ChemMedChem> Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug-Resistant Pathogens: Structure-Activity Relationships.

Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug-Resistant Pathogens: Structure-Activity Relationships.

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作者： Tiziano,Marzo ^[1] ; Damiano,Cirri ^[2] ; Simona,Pollini ^[1] ; Marco,Prato ^[3] ; Stefania,Fallani ^[4] ; Maria Iris,Cassetta ^[3] ; Andrea,Novelli ^[5] ; Gian Maria,Rossolini ^[5] ; Luigi,Messori ^[5]

作者单位： Laboratory of Metals in Medicine (MetMed), Department of Chemistry "U. Schiff", University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino, Italy. ^[1] Department of Chemistry and Industrial Chemistry (DCCI), University of Pisa, Via Moruzzi 13, 56124, Pisa, Italy. ^[2] Department of Experimental and Clinical Medicine (DMSC), University of Florence, Largo Brambilla 3, 50134, Firenze, Italy. ^[3] Microbiology and Virology Unit, Azienda Ospedaliero-Universitaria Careggi (AOUC), Largo Brambilla 3, 50134, Firenze, Italy. ^[4] Department of Health Sciences (DSS), University of Florence, Viale Pieraccini 6, 50139, Florence, Italy. ^[5]

关键词 antimicrobial drugs auranofin drug repositioning drug resistance gold compounds

主题词抗菌药(Anti-Bacterial Agents);抗真菌药(Antifungal Agents);金诺芬(Auranofin);白色念珠菌(Candida albicans);配位络合物(Coordination Complexes);抗药性, 多种, 细菌(Drug Resistance, Multiple, Bacterial);金(Gold);革兰氏阴性菌(Gram-Negative Bacteria);革兰氏阳性菌(Gram-Positive Bacteria);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);银(Silver);构效关系(Structure-Activity Relationship)

DOI 10.1002/cmdc.201800498

PMID 30252208

发布时间 2019-09-16

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ChemMedChem

ChemMedChem

2018年13卷22期

2448-2454页

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