换一批Clinical pharmacokinetics, pharmacodynamics, safety, and tolerability of JNJ-54175446, a brain permeable P2X7 antagonist, in a randomised single-ascending dose study in healthy participants.
第一作者：
Maarten,Timmers
第一单位：
1 Janssen Research and Development, Beerse, Belgium.;2 Reference Centre for Biological Markers of Dementia (BIODEM), University of Antwerp, Antwerp, Belgium.
作者：
医学主题词
投药, 口服(Administration, Oral);青少年(Adolescent);成年人(Adult);老年人(Aged);曲线下面积(Area Under Curve);生物利用度(Biological Availability);脑(Brain);剂量效应关系, 药物(Dose-Response Relationship, Drug);双盲法(Double-Blind Method);女(雌)性(Female);食品药物相互作用(Food-Drug Interactions);人类(Humans);半数抑制浓度(Inhibitory Concentration 50);白细胞介素1β(Interleukin-1beta);脂多糖类(Lipopolysaccharides);男(雄)性(Male);中年人(Middle Aged);嘌呤能P2X受体拮抗剂(Purinergic P2X Receptor Antagonists);吡啶类(Pyridines);组织分布(Tissue Distribution);三唑类(Triazoles);青年人(Young Adult)
DOI
10.1177/0269881118800067
PMID
30260294
发布时间
2020-01-24
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