Elucidation of pharmacokinetics of novel DNA ligase I inhibitor, S012-1332 in rats: Integration of in vitro and in vivo findings.

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作者： Mohammed,Riyazuddin ^[1] ; Guru R,Valicherla ^[2] ; Athar,Husain ^[1] ; Mohd Kamil,Hussain ^[3] ; Minakshi,Shukla ^[4] ; Roshan,Katekar ^[1] ; Anand P,Gupta ^[1] ; Pragati,Singh ^[1] ; Dibyendu,Banerjee ^[5] ; Kanchan,Hajela ^[3] ; Jiaur R,Gayen ^[6]

作者单位： Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India. ^[1] Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. ^[2] Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India. ^[3] Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Raibarelly, 229010, India. ^[4] Molecular & Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. ^[5] Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Electronic address: jr.gayen@cdri.res.in. ^[6]

关键词 In vitro metabolism LC-ESI-MS/MS Plasma protein binding Preclinical pharmacokinetics S012-1332