Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics.

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第一作者： Lucas L,Baltussen

第一单位： Kinases and Brain Development Laboratory, The Francis Crick Institute, London, UK.

作者： Lucas L,Baltussen ^[1] ; Priscilla D,Negraes ^[2] ; Margaux,Silvestre ^[1] ; Suzanne,Claxton ^[1] ; Max,Moeskops ^[1] ; Evangelos,Christodoulou ^[3] ; Helen R,Flynn ^[4] ; Ambrosius P,Snijders ^[4] ; Alysson R,Muotri ^[5] ; Sila K,Ultanir ^[6]

作者单位： Kinases and Brain Development Laboratory, The Francis Crick Institute, London, UK. ^[1] Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA. ^[2] Structural Biology Science Technology Platform, The Francis Crick Institute, London, UK. ^[3] Proteomics Science Technology Platform, The Francis Crick Institute, London, UK. ^[4] Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA, USA muotri@ucsd.edu sila.ultanir@crick.ac.uk.;Department of Pediatrics/Cellular & Molecular Medicine, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, School of Medicine, Rady Children's Hospital San Diego, University of California San Diego, La Jolla, CA, USA. ^[5] Kinases and Brain Development Laboratory, The Francis Crick Institute, London, UK muotri@ucsd.edu sila.ultanir@crick.ac.uk. ^[6]

关键词 CDKL5 EB2 MAP1S chemical genetics microtubule dynamics