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Acridine-based (thio)semicarbazones and hydrazones: Synthesis, in vitro urease inhibition, molecular docking and in-silico ADME evaluation.

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第一作者： Ibanga Okon,Isaac

第一单位： H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

作者： Ibanga Okon,Isaac ^[1] ; Mariya,Al-Rashida ^[2] ; Shafiq Ur,Rahman ^[3] ; Rima D,Alharthy ^[4] ; Asnuzilawati,Asari ^[5] ; Abdul,Hameed ^[6] ; Khalid Mohammed,Khan ^[7] ; Jamshed,Iqbal ^[8]

作者单位： H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. ^[1] Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan. ^[2] Center for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. ^[3] Department of Chemistry, Science and Arts College, Rabigh Campus, King Abdulaziz University, Jeddah, Saudi Arabia. ^[4] School of Fundamental Science, Universiti Malaysia Terengganu, 21030 Kuala Nerus, Terengganu, Malaysia. ^[5] H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: abdul_hameed8@hotmail.com. ^[6] H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, P.O. Box 31441, Dammam, Saudi Arabia. ^[7] Center for Advanced Drug Research, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan. Electronic address: drjamshed@ciit.net.pk. ^[8]

关键词 (Thio)semicarbazones Acridine In silico ADME Pathogenic bacteria Urease inhibition