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Simultaneous zygotic inactivation of multiple genes in mouse through CRISPR/Cas9-mediated base editing.

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第一作者: He,Zhang
第一单位: Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.;University of Chinese Academy of Sciences, Beijing 100049, China.
作者: He,Zhang [1] ; Hong,Pan [2] ; Changyang,Zhou [1] ; Yu,Wei [3] ; Wenqin,Ying [3] ; Shuting,Li [3] ; Guangqin,Wang [3] ; Chao,Li [3] ; Yifei,Ren [1] ; Gen,Li [4] ; Xu,Ding [4] ; Yidi,Sun [5] ; Geng-Lin,Li [6] ; Lei,Song [4] ; Yixue,Li [7] ; Hui,Yang [8] ; Zhiyong,Liu [8]
作者单位: Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.;University of Chinese Academy of Sciences, Beijing 100049, China. [1] Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.;Guangxi University, Nanning 530004, Guangxi, China. [2] Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. [3] Department of Otolaryngology, Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.;Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.;Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200011, China. [4] University of Chinese Academy of Sciences, Beijing 100049, China.;Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. [5] Department of Otolaryngology, Head and Neck Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.;Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.;Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai 200011, China.;Biology Department, University of Massachusetts Amherst, Amherst, MA 01003, USA. [6] University of Chinese Academy of Sciences, Beijing 100049, China.;Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.;Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai 200032, China.;Shanghai Center for Bioinformation Technology, Shanghai Industrial Technology Institute, Shanghai 200032, China. [7] Institute of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China huiyang@ion.ac.cn zhiyongliu@ion.ac.cn. [8]
DOI 10.1242/dev.168906
PMID 30275281
发布时间 2019-02-15
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