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NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy.

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第一作者： Qun,Fu

第一单位： Department of Anesthesiology, Jinling Hospital, Medical College of Nanjing Medical University, Nanjing, 210002, China.;Department of Anesthesiology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China.

作者： Qun,Fu ^[1] ; Jing,Wu ^[2] ; Xiao-Yan,Zhou ^[3] ; Mu-Huo,Ji ^[4] ; Qing-Hong,Mao ^[5] ; Qing,Li ^[5] ; Man-Man,Zong ^[3] ; Zhi-Qiang,Zhou ^[6] ; Jian-Jun,Yang ^[7]

作者单位： Department of Anesthesiology, Jinling Hospital, Medical College of Nanjing Medical University, Nanjing, 210002, China.;Department of Anesthesiology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China. ^[1] Jiangsu Key Laboratory of Molecular Medicine, Medical School of Nanjing University, Nanjing, 210093, China.;Department of Anesthesiology, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. ^[2] Department of Anesthesiology, Jinling Hospital, Medical College of Nanjing Medical University, Nanjing, 210002, China. ^[3] Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China. ^[4] Department of Anesthesiology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China. ^[5] Department of Anesthesiology, Jinling Hospital, Medical College of Nanjing Medical University, Nanjing, 210002, China. zq_zhou@163.com. ^[6] Department of Anesthesiology, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China. yjyangjj@126.com.;Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, 210009, China. yjyangjj@126.com. ^[7]

关键词 NLRP3 caspase-1 cognitive impairment pro-inflammatory cytokine pyroptosis

医学主题词动物(Animals);半胱氨酸天冬氨酸蛋白酶1(Caspase 1);认知障碍(Cognition Disorders);细胞因子类(Cytokines);海马(Hippocampus);小鼠(Mice)

DOI 10.1007/s10753-018-0894-4

PMID 30276509

发布时间 2020-02-25

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