首页> Molecular psychiatry> Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

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第一作者： Mickael,Audrain

第一单位： Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

作者： Mickael,Audrain ^[1] ; Jean-Vianney,Haure-Mirande ^[1] ; Minghui,Wang ^[2] ; Soong Ho,Kim ^[1] ; Tomas,Fanutza ^[1] ; Paramita,Chakrabarty ^[3] ; Paul,Fraser ^[4] ; Peter H,St George-Hyslop ^[4] ; Todd E,Golde ^[3] ; Robert D,Blitzer ^[5] ; Eric E,Schadt ^[2] ; Bin,Zhang ^[2] ; Michelle E,Ehrlich ^[6] ; Sam,Gandy ^[7]

作者单位： Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[1] Department of Genetics and Genomic Sciences and Icahn Institute of Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[2] Department of Neuroscience and McKnight Brain Institute, University of Florida, Gainesville, FL, 32610, USA. ^[3] Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. ^[4] Departments of Pharmacological Sciences and Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. ^[5] Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. michelle.ehrlich@mssm.edu.;Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. michelle.ehrlich@mssm.edu. ^[6] Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. samuel.gandy@mssm.edu.;Department of Psychiatry and Alzheimer's Disease Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. samuel.gandy@mssm.edu. ^[7]