Synthetic Lethality and Cancer - Penetrance as the Major Barrier.

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第一作者： Colm J,Ryan

第一单位： School of Computer Science and Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: colm.ryan@ucd.ie.

作者： Colm J,Ryan ^[1] ; Ilirjana,Bajrami ^[2] ; Christopher J,Lord ^[3]

作者单位： School of Computer Science and Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: colm.ryan@ucd.ie. ^[1] Breast Cancer Now Toby Robins Research Centre and Cancer Research UK (CRUK) Gene Function Laboratory, Institute of Cancer Research (ICR), London SW3 6JB, UK. Electronic address: Ilirjana.Bajrami@icr.ac.uk. ^[2] Breast Cancer Now Toby Robins Research Centre and Cancer Research UK (CRUK) Gene Function Laboratory, Institute of Cancer Research (ICR), London SW3 6JB, UK. Electronic address: chris.lord@icr.ac.uk. ^[3]

关键词 genetic screening heterogeneity penetrance robustness synthetic lethality

主题词计算生物学(Computational Biology);人类(Humans);分子靶向治疗(Molecular Targeted Therapy);肿瘤(Neoplasms);癌基因(Oncogenes);外显率(Penetrance);RNA干扰(RNA Interference)

DOI 10.1016/j.trecan.2018.08.003

PMID 30292351

发布时间 2024-02-10

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Trends in cancer

2018年4卷10期

671-683页

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Synthetic Lethality and Cancer - Penetrance as the Major Barrier.

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Synthetic Lethality and Cancer - Penetrance as the Major Barrier.

Trends in cancer

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Trends in cancer

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