MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.-论文-万方医学网

第一作者： Louise,Fets

第一单位： Cancer Metabolism Laboratory, Francis Crick Institute, London, UK.

作者： Louise,Fets ^[1] ; Paul C,Driscoll ^[2] ; Fiona,Grimm ^[1] ; Aakriti,Jain ^[1] ; Patrícia M,Nunes ^[1] ; Michalis,Gounis ^[1] ; Ginevra,Doglioni ^[1] ; George,Papageorgiou ^[3] ; Timothy J,Ragan ^[4] ; Sebastien,Campos ^[5] ; Mariana,Silva Dos Santos ^[2] ; James I,MacRae ^[2] ; Nicola,O'Reilly ^[3] ; Alan J,Wright ^[6] ; Cyril H,Benes ^[7] ; Kevin D,Courtney ^[8] ; David,House ^[5] ; Dimitrios,Anastasiou ^[9]

作者单位： Cancer Metabolism Laboratory, Francis Crick Institute, London, UK. ^[1] Metabolomics Science Technology Platform, Francis Crick Institute, London, UK. ^[2] Peptide Chemistry Science Technology Platform, Francis Crick Institute, London, UK. ^[3] MRC-National Institute for Medical Research, London, UK. ^[4] Crick-GSK Biomedical LinkLabs, GSK Medicines Research Centre, Stevenage, UK. ^[5] Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK. ^[6] Massachusetts General Hospital Cancer Center & Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[7] Department of Internal Medicine, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[8] Cancer Metabolism Laboratory, Francis Crick Institute, London, UK. dimitrios.anastasiou@crick.ac.uk. ^[9]

医学主题词腺苷三磷酸(Adenosine Triphosphate);氨基酸类, 二羧酸(Amino Acids, Dicarboxylic);动物(Animals);生化现象(Biochemical Phenomena);牛(Cattle);细胞系, 肿瘤(Cell Line, Tumor);柠檬酸循环(Citric Acid Cycle);基因表达谱(Gene Expression Profiling);谷氨酰胺(Glutamine);人类(Humans);水解作用(Hydrolysis);半数抑制浓度(Inhibitory Concentration 50);酮戊二酸类(Ketoglutaric Acids);代谢组学(Metabolomics);小鼠(Mice);线粒体(Mitochondria);一元羧酸转运子(Monocarboxylic Acid Transporters);氧(Oxygen);嘌呤霉素(Puromycin);信号传导(Signal Transduction);三羧酸类(Tricarboxylic Acids)

DOI 10.1038/s41589-018-0136-y

PMID 30297875

发布时间 2025-05-30

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MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.

Nature chemical biology

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MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.

Nature chemical biology

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Nature chemical biology

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