A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing.

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作者： Silvia,Stotani ^[1] ; Viviana,Gatta ^[2] ; Federico,Medda ^[3] ; Mohan,Padmanaban ^[4] ; Anna,Karawajczyk ^[5] ; Päivi,Tammela ^[6] ; Fabrizio,Giordanetto ^[7] ; Dimitrios,Tzalis ^[8] ; Simona,Collina ^[9]

作者单位： Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. silviastotani@hotmail.it. ^[1] Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. silviastotani@hotmail.it. ^[2] Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. viviana.gatta@helsinki.fi. ^[3] Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. fmedda@centurionbiopharma.com. ^[4] Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. mpadmanaban@taros.de. ^[5] Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. akarawajczyk@gmail.com. ^[6] Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. paivi.tammela@helsinki.fi. ^[7] Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. Fabrizio.Giordanetto@deshawresearch.com. ^[8] Medicinal Chemistry, Taros Chemicals GmbH & Co. KG, Emil-Figge-Straße 76a, 44227 Dortmund, Germany. dtzalis@taros.de. ^[9] Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. simona.collina@unipv.it. ^[10]

关键词 DPD DPD-related compounds antibiotic resistance quorum sensing