The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract.

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作者： Jose M,Bravo-Arredondo ^[1] ; Natalie C,Kegulian ^[2] ; Thomas,Schmidt ^[3] ; Nitin K,Pandey ^[3] ; Alan J,Situ ^[1] ; Tobias S,Ulmer ^[1] ; Ralf,Langen ^[1]

作者单位： From the Departments of Physiology and Neuroscience and. ^[1] the Facultad de Ciencias Básicas, Ingeniería y Tecnología, Universidad Autónoma de Tlaxcala, Calzada Apizaquito S/N, 90300 Apizaco, Tlaxcala, Mexico. ^[2] Biochemistry and Molecular Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 and. ^[3] From the Departments of Physiology and Neuroscience and langen@usc.edu. ^[4]

关键词 Huntington disease conformational equilibrium electron paramagnetic resonance (EPR)neurodegeneration nuclear magnetic resonance (NMR)polyglutamine protein misfolding

主题词外显子(Exons);人类(Humans);模型, 分子(Models, Molecular);肽类(Peptides);蛋白质折叠(Protein Folding);温度(Temperature)

DOI 10.1074/jbc.RA118.004808

PMID 30315108

发布时间 2021-02-05

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