Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals.

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作者： Sun-Ho,Han ^[1] ; Jong-Chan,Park ^[2] ; Min Soo,Byun ^[3] ; Dahyun,Yi ^[3] ; Jun Ho,Lee ^[4] ; Dong Young,Lee ^[5] ; Inhee,Mook-Jung ^[6] ; KBASE Research Group

作者单位： Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea; Neuroscience Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea. ^[1] Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea. ^[2] Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. ^[3] Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea. ^[4] Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea; Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; Department of Psychiatry, College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address: selfpsy@snu.ac.kr. ^[5] Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea; Neuroscience Research Institute, College of Medicine, Seoul National University, Seoul, Republic of Korea. Electronic address: inhee@snu.ac.kr. ^[6]

关键词 Acetylcholinesterase Alzheimer's disease Blood-based biomarker Cerebral Aβ deposition PiB-PET β-amyloid