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Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O<sub>2-</sub>· production in cancer cells.

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第一作者: Marco,Cordani
第一单位: Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy.;Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain.
作者单位: Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy.;Biochemistry Department, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas "Alberto Sols" (CSIC-UAM), IdiPAZ, Madrid, Spain. [1] Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy. [2] Grupo Multidisciplinar de Oncología Traslacional, Instituto Universitario de Investigación en Ciencias de la Salud (IUNICS), Palma de Mallorca, Illes Balears, Spain.;Ciber Fisiopatología Obesidad y Nutrición (CB06/03), Instituto Salud Carlos III, Madrid, Spain.;Instituto de Investigación Sanitaria de Palma (IdISPa), Hospital Universitario Son Espases, edificio S. E-07120, Palma de Mallorca, Illes Balears, Spain. [3] Research Center LURM (Interdepartmental Laboratory of Medical Research), University of Verona, Verona, Italy. [4] Department of Medicine, Section of General Pathology, University of Verona, Verona, Italy. [5] Vall d'Hebron Institut d'Oncologia (VHIO), Barcelona, Spain.;CIBERONC, Madrid, Spain. [6] Division of Molecular Oncology, Department of Translational Research, CRO National Cancer Institute Aviano, Aviano, Italy. [7] Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.;Institute of Oncology Research, Bellinzona, Switzerland. [8] Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy. [9] Department of Biochemistry, Biophysics and General Pathology, University of Campania "L. Vanvitelli", Naples, Italy. [10] Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biochemistry, University of Verona, Verona, Italy. massimo.donadelli@univr.it. [11]
DOI 10.1038/s41416-018-0288-2
PMID 30318520
发布时间 2020-03-09
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British journal of cancer

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