Hypoxia increases chemoresistance in human medulloblastoma DAOY cells via hypoxia‑inducible factor 1α‑mediated downregulation of the CYP2B6, CYP3A4 and CYP3A5 enzymes and inhibition of cell proliferation.
作者:
主题词
细胞低氧(Cell Hypoxia);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);小脑肿瘤(Cerebellar Neoplasms);环磷酰胺(Cyclophosphamide);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);减量调节(Down-Regulation);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);异环磷酰胺(Ifosfamide);髓母细胞瘤(Medulloblastoma)
DOI
10.3892/or.2018.6790
PMID
30320358
发布时间
2020-02-25
- 浏览14

Oncology reports
178-190页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文