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Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization.

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第一作者： T R,Hörmann

第一单位： Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13/3, 8010 Graz, Austria.

作者： T R,Hörmann ^[1] ; N,Jäger ^[2] ; A,Funke ^[3] ; R-K,Mürb ^[4] ; J G,Khinast ^[5] ; A,Paudel ^[6]

作者单位： Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13/3, 8010 Graz, Austria. ^[1] Research Centre for Pharmaceutical Engineering, Inffeldgasse 13/2, 8010 Graz, Austria. ^[2] Chemical and Pharmaceutical Development, Bayer AG, Müllerstraße 178, 13353 Berlin, Germany. ^[3] Maag Automatik GmbH, Ostring 19, 63762 Großostheim, Germany. ^[4] Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13/3, 8010 Graz, Austria; Research Centre for Pharmaceutical Engineering, Inffeldgasse 13/2, 8010 Graz, Austria. Electronic address: khinast@tugraz.at. ^[5] Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13/3, 8010 Graz, Austria; Research Centre for Pharmaceutical Engineering, Inffeldgasse 13/2, 8010 Graz, Austria. Electronic address: amrit.paudel@rcpe.at. ^[6]

关键词 Amorphous solid dispersion Dual-polymeric carrier formulation Hot-melt extrusion Molecular interactions Nimodipine Strand pelletization