Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response.

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作者： Assaf,Marcus ^[1] ; Amy J,Mao ^[1] ; Monisha,Lensink-Vasan ^[1] ; LeeAnn,Wang ^[1] ; Russell E,Vance ^[2] ; David H,Raulet ^[3]

作者单位： Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. ^[1] Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA; Immunotherapeutics and Vaccine Research Initiative, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rvance@berkeley.edu. ^[2] Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Cancer Research Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA; Immunotherapeutics and Vaccine Research Initiative, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: raulet@berkeley.edu. ^[3]

关键词 -cGAMP 2?3?DNA sensor NK cells STING cGAS cancer immunology cancer immunotherapy interferon natural killer cells tumor immunity