Synthesis and Docking Study of Novel 4-Thiazolidinone Derivatives as Anti-Gram-positive and Anti-H. pylori Agents.

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作者： Armin,Khomami ^[1] ; Mohammadamin,Rahimi ^[1] ; Arash,Tabei ^[1] ; Parastoo,Saniee ^[2] ; Arash,Mahboubi ^[3] ; Alireza,Foroumadi ^[4] ; Nasrin Nassiri,Koopaei ^[1] ; Ali,Almasirad ^[1]

作者单位： Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. ^[1] Department of Microbiology and Microbial Biotechnology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University G.C, Tehran, Iran. ^[2] Food Safety Research Center, Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ^[3] Department of Medicinal Chemistry, Faculty of Pharmacy and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran. ^[4]

关键词 1,3,4-Thiadiazole Autodock 4.2 Gram-positive H. pylori MURB Nitrothiophene Urease.

主题词抗菌药(Anti-Bacterial Agents);革兰氏阳性菌(Gram-Positive Bacteria);幽门螺杆菌(Helicobacter pylori);蛋白质构象(Protein Conformation);构效关系(Structure-Activity Relationship);噻唑烷类(Thiazolidines);尿素酶(Urease)

DOI 10.2174/1389557518666181017142630

PMID 30332951

发布时间 2019-03-04

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