Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation.

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第一作者： Gustav,Ahlberg

第一单位： Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, 2100 Ø, Denmark.

作者： Gustav,Ahlberg ^[1] ; Lena,Refsgaard ^[2] ; Pia R,Lundegaard ^[1] ; Laura,Andreasen ^[2] ; Mattis F,Ranthe ^[1] ; Nora,Linscheid ^[2] ; Jonas B,Nielsen ^[1] ; Mads,Melbye ^[2] ; Stig,Haunsø ^[3] ; Ahmad,Sajadieh ^[4] ; Lu,Camp ^[5] ; Søren-Peter,Olesen ^[6] ; Simon,Rasmussen ^[3] ; Alicia,Lundby ^[6] ; Patrick T,Ellinor ^[7] ; Anders G,Holst ^[1] ; Jesper H,Svendsen ^[8] ; Morten S,Olesen ^[9]

作者单位： Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, 2100 Ø, Denmark. ^[1] Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200 N, Denmark. ^[2] Department of Epidemiology Research, Statens Serum Institute, Copenhagen, 2300 S, Denmark. ^[3] Cardiac Proteomics Group, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200 N, Denmark. ^[4] Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200 N, Denmark. ^[5] Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200 N, Denmark. ^[6] Department of Medicine, Stanford University School of Medicine, Stanford, 94305, CA, USA. ^[7] Department of Cardiology, Copenhagen University Hospital, Bispebjerg, Copenhagen, 2400, Denmark. ^[8] The Lundbeck Foundation Centre for Applied Medical Genomics in Personalized Disease Prediction, Prevention and Care, Copenhagen, 2200 N, Denmark. ^[9] Department of Bio and Health Informatics, Technical University of Denmark, Kgs, Lyngby, 2800, Denmark. ^[10] Cardiovascular Research Centre, Massachusetts General Hospital, Boston, 02114, MA, USA. ^[11] Program in Population and Medical Genetics, The Broad Institute of Harvard and MIT, Cambridge, 02114, MA, USA. ^[12] Laboratory for Molecular Cardiology, Department of Cardiology, The Heart Centre, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, 2100 Ø, Denmark. mortensol@sund.ku.dk. ^[13] Department of Biomedical Sciences, University of Copenhagen, Copenhagen, 2200 N, Denmark. mortensol@sund.ku.dk. ^[14]