Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass.

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作者： James,Cantley ^[1] ; Aimee,Davenport ^[2] ; Laurène,Vetterli ^[3] ; Nandor J,Nemes ^[3] ; P Tess,Whitworth ^[2] ; Ebru,Boslem ^[2] ; Le May,Thai ^[2] ; Natalie,Mellett ^[4] ; Peter J,Meikle ^[4] ; Kyle L,Hoehn ^[5] ; David E,James ^[6] ; Trevor J,Biden ^[7]

作者单位： Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. james.cantley@dpag.ox.ac.uk. ^[1] Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia. ^[2] Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, OX1 3PT, UK. ^[3] Baker IDI Heart and Diabetes Institute, Melbourne, VIC, Australia. ^[4] School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia. ^[5] The Charles Perkins Centre, School of Molecular Biosciences, School of Medicine, University of Sydney, Sydney, NSW, Australia. ^[6] Diabetes and Obesity Research Program, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.;St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Darlinghurst, NSW, Australia. ^[7]

关键词 ACC1 Beta cell Insulin secretion Islet Lipid metabolism Mouse mTOR