Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease.-论文-万方医学网

作者： Marta,Garcia-Miralles ^[1] ; Nur Amirah Binte Mohammad,Yusof ^[1] ; Jing Ying,Tan ^[1] ; Carola I,Radulescu ^[1] ; Harwin,Sidik ^[1] ; Liang Juin,Tan ^[1] ; Haim,Belinson ^[2] ; Neta,Zach ^[2] ; Michael R,Hayden ^[1] ; Mahmoud A,Pouladi ^[2]

作者单位： Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore. ^[1] Teva Pharmaceutical Industries Ltd, Research and Development, Netanya, Israel. ^[2] Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada. ^[3] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. ^[4] Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore (A*STAR), 8A Biomedical Grove, Immunos, Level 5, Singapore, 138648, Singapore. pouladi@tlgm.a-star.edu.sg. ^[5] Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore. pouladi@tlgm.a-star.edu.sg. ^[6]

主题词动物(Animals);星形细胞(Astrocytes);行为, 动物(Behavior, Animal);细胞计数(Cell Count);胼胝体(Corpus Callosum);纹状体(Corpus Striatum);细胞色素P450 CYP1A1(Cytochrome P-450 CYP1A1);抑郁(Depression);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);基因表达调控(Gene Expression Regulation);人类(Humans);杭廷顿病(Huntington Disease);炎症(Inflammation);学习(Learning);男(雄)性(Male);小鼠, 转基因(Mice, Transgenic);小神经胶质细胞(Microglia);运动活动(Motor Activity);髓鞘(Myelin Sheath);少突神经胶质(Oligodendroglia);表型(Phenotype);喹诺酮类(Quinolones);受体, 芳基烃(Receptors, Aryl Hydrocarbon);转录, 遗传(Transcription, Genetic)

DOI 10.1007/s12035-018-1393-1

PMID 30334188

发布时间 2021-01-09

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Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease.

Molecular neurobiology

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Molecular neurobiology

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Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease.

Molecular neurobiology

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Molecular neurobiology

相关期刊

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