Specificity landscapes unmask submaximal binding site preferences of transcription factors.

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第一作者： Devesh,Bhimsaria

第一单位： Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.;Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706.

作者： Devesh,Bhimsaria ^[1] ; José A,Rodríguez-Martínez ^[2] ; Junkun,Pan ^[3] ; Daniel,Roston ^[3] ; Elif Nihal,Korkmaz ^[3] ; Qiang,Cui ^[3] ; Parameswaran,Ramanathan ^[4] ; Aseem Z,Ansari ^[5]

作者单位： Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.;Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706. ^[1] Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706. ^[2] Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706. ^[3] Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI 53706. ^[4] Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706; azansari@wisc.edu.;The Genome Center of Wisconsin, University of Wisconsin-Madison, Madison, WI 53706. ^[5]

关键词 DNA sequence recognition DNA–protein interactome Differential Specificity and Energy Landscapes allostery cognate site identification

主题词结合部位(Binding Sites);DNA(DNA);SELEX适体技术(SELEX Aptamer Technique);热力学(Thermodynamics);转录因子(Transcription Factors)

DOI 10.1073/pnas.1811431115

PMID 30341220

发布时间 2019-05-22

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