Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1.

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作者： Lihong,Wang-Bishop ^[1] ; Zheng,Chen ^[2] ; Ahmed,Gomaa ^[2] ; Albert Craig,Lockhart ^[3] ; Safia,Salaria ^[4] ; Jialiang,Wang ^[4] ; Keeli B,Lewis ^[4] ; Jeffrey,Ecsedy ^[5] ; Kay,Washington ^[4] ; Robert Daniel,Beauchamp ^[6] ; Wael,El-Rifai ^[7]

作者单位： Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, Tennessee. ^[1] Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida. ^[2] Division of Medical Oncology, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida. ^[3] Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. ^[4] Translational Medicine, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts. ^[5] Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee. ^[6] Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, Florida; Department of Veterans Affairs, Miami VA Healthcare system, Miami, Florida. Electronic address: welrifai@med.miami.edu. ^[7]

关键词 Colon Cancer Mutation Oncogenic Signal Transduction