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A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition.

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第一作者： Georg,Mohr

第一单位： Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA.

作者： Georg,Mohr ^[1] ; Sukrit,Silas ^[2] ; Jennifer L,Stamos ^[1] ; Kira S,Makarova ^[3] ; Laura M,Markham ^[1] ; Jun,Yao ^[1] ; Patricia,Lucas-Elío ^[4] ; Antonio,Sanchez-Amat ^[4] ; Andrew Z,Fire ^[5] ; Eugene V,Koonin ^[3] ; Alan M,Lambowitz ^[6]

作者单位： Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. ^[1] Department of Pathology, Stanford University, Stanford, CA 94305, USA; Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA. ^[2] National Center for Biotechnology Information, National Library of Medicine, NIH, Bethesda, MD 20894, USA. ^[3] Department of Genetics and Microbiology, Universidad de Murcia, Murcia 30100, Spain. ^[4] Department of Pathology, Stanford University, Stanford, CA 94305, USA. ^[5] Institute for Cellular and Molecular Biology and Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, USA. Electronic address: lambowitz@austin.utexas.edu. ^[6]

关键词 CRISPR adaptation CRISPR-Cas Cas1 adaptive immunity crRNA processing crystal structure evolution fusion protein reverse transcriptase