A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies.

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第一作者： Marlon H,Cardoso

第一单位： Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina , Universidade de Brasília , Campus Darcy Ribeiro, Asa Norte , Brasília , DF 70910900 , Brazil.

作者： Marlon H,Cardoso ^[1] ; Elizabete S,Cândido ^[2] ; Lai Y,Chan ^[3] ; Marcelo,Der Torossian Torres ^[4] ; Karen G N,Oshiro ^[2] ; Samilla B,Rezende ^[3] ; William F,Porto ^[4] ; Timothy K,Lu ^[5] ; Cesar,de la Fuente-Nunez ^[6] ; David J,Craik ^[7] ; Octávio L,Franco ^[1]

作者单位： Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina , Universidade de Brasília , Campus Darcy Ribeiro, Asa Norte , Brasília , DF 70910900 , Brazil. ^[1] Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia , Universidade Católica de Brasília , SGAN 916 Módulo B, Asa Norte , Brasília , DF 70790160 , Brazil. ^[2] S-inova Biotech, Programa de Pós-Graduação em Biotecnologia , Universidade Católica Dom Bosco Avenida Tamandaré 6000 , Campo Grande , MS 79117900 , Brazil. ^[3] Institute for Molecular Bioscience , The University of Queensland , 306 Carmody Road , Brisbane , QLD 4072 , Australia. ^[4] Synthetic Biology Group, MIT Synthetic Biology Center; The Center for Microbiome Informatics and Therapeutics; Research Laboratory of Electronics, Department of Biological Engineering, and Department of Electrical Engineering and Computer Science , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States. ^[5] Broad Institute of MIT and Harvard , Cambridge , Massachusetts 02139 , United States. ^[6] Centro de Ciências Naturais e Humanas , Universidade Federal do ABC , Santo André , SP 09210170 , Brazil. ^[7] Porto Reports , Brasília , DF 70790160 , Brazil. ^[8]

关键词 antimicrobial peptides bacterial biofilm bacterial resistance biophysics skin infection

主题词动物(Animals);抗菌药(Anti-Bacterial Agents);抗微生物阳离子肽类(Antimicrobial Cationic Peptides);生物膜(Biofilms);圆二色性(Circular Dichroism);计算机辅助设计(Computer-Aided Design);药物设计(Drug Design);大肠杆菌(Escherichia coli);女(雌)性(Female);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);小鼠(Mice);微生物敏感性试验(Microbial Sensitivity Tests);假单胞菌感染(Pseudomonas Infections);铜绿假单胞菌(Pseudomonas aeruginosa)

DOI 10.1021/acsinfecdis.8b00219

PMID 30346140

发布时间 2019-10-07

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ACS infectious diseases

2018年4卷12期

1727-1736页

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A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies.

ACS infectious diseases

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A Computationally Designed Peptide Derived from Escherichia coli as a Potential Drug Template for Antibacterial and Antibiofilm Therapies.

ACS infectious diseases

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ACS infectious diseases

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