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Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity.

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第一作者： Frederique,Ruf-Zamojski

第一单位： Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

作者： Frederique,Ruf-Zamojski ^[1] ; Yongchao,Ge ^[1] ; Venugopalan,Nair ^[1] ; Michel,Zamojski ^[1] ; Hanna,Pincas ^[1] ; Chirine,Toufaily ^[2] ; Jessica,Tome-Garcia ^[3] ; Marlon,Stoeckius ^[4] ; William,Stephenson ^[4] ; Gregory R,Smith ^[1] ; Daniel J,Bernard ^[2] ; Nadejda M,Tsankova ^[3] ; Boris M,Hartmann ^[1] ; Miguel,Fribourg ^[1] ; Peter,Smibert ^[4] ; Harold,Swerdlow ^[4] ; Judith L,Turgeon ^[5] ; Stuart C,Sealfon ^[6]

作者单位： Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[1] Dept. of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada. ^[2] Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.;Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.;Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[3] New York Genome Center, New York, NY 10013, USA. ^[4] Department of Internal Medicine, University of California, Davis, CA 95616, USA. ^[5] Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.;Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ^[6]

医学主题词动物(Animals);缓冲剂(Buffers);细胞系, 肿瘤(Cell Line, Tumor);剂量效应关系, 药物(Dose-Response Relationship, Drug);早期生长反应蛋白质1(Early Growth Response Protein 1);早期生长反应蛋白质2(Early Growth Response Protein 2);基因, 即早(Genes, Immediate-Early);遗传异质性(Genetic Heterogeneity);促性腺激素细胞(Gonadotrophs);促性腺素释放激素(Gonadotropin-Releasing Hormone);小鼠(Mice);原癌基因蛋白质c-fos(Proto-Oncogene Proteins c-fos);RNA稳定性(RNA Stability);RNA, 信使(RNA, Messenger);序列分析, RNA(Sequence Analysis, RNA);单细胞分析(Single-Cell Analysis);转录激活(Transcriptional Activation)

DOI 10.1093/nar/gky991

PMID 30357357

发布时间 2022-08-27

基金项目

R56 DK046943/DK/NIDDK NIH HHS/United States MOP-123447/CIHR/Canada R01 DK046943/DK/NIDDK NIH HHS/United States S10 OD018522/OD/NIH HHS/United States U19 AI117873/AI/NIAID NIH HHS/United States U19 AI117905/AI/NIAID NIH HHS/United States

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