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DNA hypermethylation within TERT promoter upregulates TERT expression in cancer.

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作者单位: Program in Genetics and Genome Biology, and. [1] The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. [2] Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. [3] Faculty of Medicine, University of Coimbra, Coimbra, Portugal. [4] Departments of Physiology and Pharmacology, Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada. [5] Department of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, Germany. [6] Department of Biomedical Sciences and Medicine, and. [7] Centro Hospitalar Universitário do Algarve, Faro, Portugal. [8] Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. [9] Department of Urology, University Hospital Zürich, and. [10] Institute of Pathology and Molecular Pathology, University Hospital Zürich, University of Zürich, Zürich, Switzerland. [11] Division of Neurosurgery, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada. [12] Department of Pathology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. [13] Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada. [14] Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. [15] Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. [16] Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. [17] Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA. [18] Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada. [19] Division of Hematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada. [20]
DOI 10.1172/JCI121303
PMID 30358567
发布时间 2020-03-09
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