Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion activity by interacting with acidic phospholipids.

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第一作者： Jia,Wang

第一单位： From the State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084.

作者： Jia,Wang ^[1] ; Chengsong,Yan ^[2] ; Chenqi,Xu ^[2] ; Boon Tin,Chua ^[3] ; Peng,Li ^[4] ; Feng-Jung,Chen ^[5]

作者单位： From the State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084. ^[1] the State Key Laboratory of Molecular Biology, Shanghai Science Research Center, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, and. ^[2] the Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China. ^[3] From the State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, li-peng@mail.tsinghua.edu.cn. ^[4] From the State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing 100084, derrick.eo93g@gmail.com.;the Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200438, China. ^[5]

关键词 CIDEC adipose tissue inhibitory regulation lipid droplet lipid droplet fusion lipid metabolism lipid storage lipid-protein interaction phospholipid polybasic RKKR motif